Scientific projects available and recruiting
Alexey Polilov is the head of work on the comprehensive study of the smallest insects. His laboratory – MicroInsectLab studies the structure and ultrastructure, flight mechanics, cognitive abilities, connectomics, genomics and others areas of studying microinsects.
Comparison of the sizes of the smallest insects and unicellular organisms
3D reconstruction of the brain and complex eyes of the miniature wasp Megaphragma amalphitanum
Small heat shock proteins (sHsp): structure, properties and functioning mechanisms studies
The structure of several small human heat shock proteins and their mutants that mimic phosphorylation and the ability of small heat shock proteins to form hetero-oligomeric complexes have been investigated. It has been shown that point mutations correlating with neurodegenerative diseases lead to a decrease in stability and a weakening of the chaperone activity of the heat shock protein HspB8. The structure and properties of the universal adapter protein 14-3-3 have been studied, and it has been suggested that this protein may play an essential role in developing some forms of neurodegenerative diseases (tauopathies).
Crystal structure of the 14-3-3σ/phosphoHspB6 regulatory complex
Changes induced in the structure and properties of Charcot-Marie-Tooth disease–associated mutants of small heat shock protein HspB1
Proteolytic enzymes of micromycetes studies
Scientific work is related to the study of proteolytic enzymes produced by micromycetes, especially representatives of the genus Aspergillus. Research is aimed at screening producers and obtaining hemostatically active proteases for the development of medical therapeutic and diagnostic drugs.